Competing endogenous RNA regulatory network of factor inhibiting HIF inhibitor as radioprotector for gastrointestinal toxicity via activating hypoxia-inducible factor-1 pathway
نویسندگان
چکیده
منابع مشابه
lactobacilli modulate hypoxia-inducible factor (hif)-1 regulatory pathway in triple negative breast cancer cell line
objective: hypoxia-inducible factor (hif)-1 plays an essential role in the body’s response to low oxygen concentrations and regulates expression of several genes implicated in homeostasis, vascularization, anaerobic metabolism as well as immunological responses. increased levels of hif-1α are associated with increased proliferation and more aggressive breast tumor development. lactobacilli have...
متن کاملHypoxia-inducible factor-1 (HIF-1).
Adaptation to low oxygen tension (hypoxia) in cells and tissues leads to the transcriptional induction of a series of genes that participate in angiogenesis, iron metabolism, glucose metabolism, and cell proliferation/survival. The primary factor mediating this response is the hypoxia-inducible factor-1 (HIF-1), an oxygen-sensitive transcriptional activator. HIF-1 consists of a constitutively e...
متن کاملHypoxia-Inducible Factor-1 (HIF-1)
Adaptation to low oxygen tension (hypoxia) in cells and tissues leads to the transcriptional induction of a series of genes that participate in angiogenesis, iron metabolism, glucose metabolism, and cell proliferation/survival. The primary factor mediating this response is the hypoxia-inducible factor-1 (HIF-1), an oxygen-sensitive transcriptional activator. HIF-1 consists of a constitutively e...
متن کاملLactobacilli Modulate Hypoxia-Inducible Factor (HIF)-1 Regulatory Pathway in Triple Negative Breast Cancer Cell Line
OBJECTIVE Hypoxia-Inducible Factor (HIF)-1 plays an essential role in the body's response to low oxygen concentrations and regulates expression of several genes implicated in homeostasis, vascularization, anaerobic metabolism as well as immunological responses. Increased levels of HIF-1α are associated with increased proliferation and more aggressive breast tumor development. Lactobacilli have ...
متن کاملOverexpression of gankyrin in mouse hepatocytes induces hemangioma by suppressing factor inhibiting hypoxia-inducible factor-1 (FIH-1) and activating hypoxia-inducible factor-1.
Gankyrin (also called p28 or PSMD10) is an oncoprotein commonly overexpressed in hepatocellular carcinomas. It consists of 7 ankyrin repeats and interacts with multiple proteins including Rb, Cdk4, MDM2 and NF-κB. To assess the oncogenic activity in vivo, we produced transgenic mice that overexpress gankyrin specifically in the hepatocytes. Unexpectedly, 5 of 7 F2 transgenic mice overexpressing...
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ژورنال
عنوان ژورنال: Molecular Therapy - Nucleic Acids
سال: 2021
ISSN: 2162-2531
DOI: 10.1016/j.omtn.2021.05.008